PhD Studentship
Design and synthesis of bromodomain (BRD) inhibitors.
University College London - School of Pharmacy
Identification of new chemical probes for the BRDs in order to explore the role of these epigenetic proteins in oncology and other diseases.
Project Description:
This programme will be focussed upon the identification of new small molecule drug candidates for bromodomain (BRD) epigenetic mechanisms and pathways.
· To identify potent and selective inhibitors of BRD proteins.
· To deliver a chemical probes for selected BRD proteins.
· Application of a preferred BRD chemical probe to underwrite and establish a fully integrated drug discovery research programme to treat human disease of high medical need in the area of oncology.
Main Methods and Techniques to be employed: This studentship will provide training in modern drug discovery. Core skills to be developed will include: (i) Medicinal chemistry principles in the design of bioactive drug candidates; (ii) Synthetic chemistry methods for efficiency in route design to target compounds; (iii) Understanding of broader principles of modern drug discovery e.g. ADME, safety, target validation, screening methods, intellectual property etc, and their interplay in successful drug design.
Contact Details of Supervisor
Name: Professor Paul Fish, newly apointed Chair of Medicinal Chemistry
Department: Pharmaceutical and Biological Chemistry
Telephone: +44 (0) 207 753 5845
E-mail: p.fish@ucl.ac.uk
Funding Details
Studentship funded by: UCL SoP
Preferred start date: October 2012
Length of studentship: 36 months
Stipend rate in the first year: SoP rate
Industrial collaborator: Structural Genomics Consortium (Oxford)
Home students, EU students, and Overseas students are eligible.
Please note that EU students are eligible for tuition fees-only studentships funded by Research Councils.
Entry Requirements
Application due date: Applications for this studentship will remain open until a suitable candidate is found.
Preferred subject of first degree : Chemistry
Preferred postgraduate or other work experience, if relevant: synthetic organic chemistry
Additional Information If you wish to apply for this studentship, please complete an application form (http://www.ucl.ac.uk/pharmacy/study/PhD) and send it together with the supporting documents to:
Email: registry@pharmacy.ac.uk & v.diran@ucl.ac.uk
Fax: 020 7753 5829
Post: UCL School of Pharmacy, 29/39 Brunswick Square, London WC1N 1AX
For any non-academic enquiries please contact:
Victor Diran Email: v.diran@ucl.ac.uk Tel.: 0207753 5976
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